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. 2018 Jul 25;10:2241–2248. doi: 10.2147/CMAR.S166789

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© 2018 Wang et al. This work is published and licensed by Dove Medical Press Limited

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PRAF2 gene and protein expression levels are increased in HCC.

Notes: (A) The mRNA levels of PRAF2 in HCC (T) and the corresponding adjacent liver tissue (N) were determined in 41 patients with qRT-PCR. (B) Expression of PRAF2 protein in 12 paired HCC and adjacent liver tissues was examined by Western blot. (C) PRAF2 expression is determined in HCC by immunohistochemistry. PRAF2 was presented predominantly in cytoplasm within tumor and adjacent nontumorous liver cells. The micrographs showed strong C1, moderate C2, and weak C3 staining in HCC, along with C4 staining in nontumorous liver tissues (left panel: magnification ×100; right panel: magnification ×400). (D) Reproducibility of the measurement in 518 patients was calculated using the Wilcoxon matched paired test.

Abbreviations: HCC, hepatocellular carcinoma; IHC, immunohistochemistry; PRAF2, prenylated Rab acceptor 1 domain family member 2; qRT-PCR, quantitative reverse transcription-polymerase chain reaction.