Table 1.
Univariate and multivariate analyses of clinicopathological and PRAF2 expression for overall survival in HCC patients (n=518)
| Variables | Univariate analysis
|
Multivariate analysis
|
||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age (<49 vs ≥49 years) | 0.911 (0.765–1.086) | 0.298 | N/A | N/A |
| Gender (female vs male) | 1.019 (0.756–1.447) | 0.900 | N/A | N/A |
| HBV (positive vs negative) | 1.124 (0.878–1.438) | 0.353 | N/A | N/A |
| Tumor size (≥5 vs <5 cm) | 1.531 (1.235–1.897) | 0.000 | 1.328 (1.014–1.694) | 0.023 |
| Tumor multiplicity (multiple vs single) | 1.259 (1.049–1.510) | 0.013 | 1.006 (0.814–1.242) | 0.959 |
| Tumor capsule (absent vs present) | 0.694 (0.579–0.832) | 0.000 | 0.813 (0.670–0.987) | 0.037 |
| Liver cirrhosis (no vs yes) | 0.740 (0.586–0.935) | 0.012 | 0.842 (0.658–1.078) | 0.173 |
| AFP (≥20 vs <20 ng/mL) | 1.438 (1.169–1.769) | 0.001 | 1.293 (1.044–1.602) | 0.019 |
| Vascular invasion (yes vs no) | 1.836 (1.478–2.280) | 0.000 | 1.279 (0.998–1.637) | 0.052 |
| Tumor differentiation | 1.440 (1.184–1.752) | 0.000 | 1.293 (1.056–1.584) | 0.013 |
| TNM (III–IV vs I–II) | 1.630 (1.364–1.949) | 0.000 | 1.208 (0.951–1.535) | 0.121 |
| LNM (yes vs no) | 1.594 (1.124–2.261) | 0.009 | 1.509 (1.049–2.171) | 0.027 |
| PRAF2 expression (high vs low) | 1.256 (1.052–1.499) | 0.011 | 1.244 (1.039–1.498) | 0.017 |
Notes: Bold values indicate statistically significant values (p<0.05)
Abbreviations: AFP, alpha-fetoprotein; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HR, hazard ratio; LNM, Lymph node metastasis; N/A, not applicable; PRAF2, prenylated Rab acceptor 1 domain family member 2.