Table 4.
Rate and adjusted odds ratios (OR) for small for gestational age birthweight (SGA) and preterm birth among the offspring of women with any form of hypertension, according to type of antihypertensive therapy received during pregnancy
Preterm birth | ||||||
SGA | Before 32 weeks | Before 37 weeks | ||||
Type of anti-hypertensive therapy | Rate (%)* | Adjusted OR (95% CI)** | Rate (%) | Adjusted OR (95% CI) | Rate (%) | Adjusted OR (95% CI) |
None | 9.0 | 1.0 | 1.9 | 1.0 | 12.2 | 1.0 |
β-blocker | 19.9 | 2.3 (1.6–3.3) | 14.7 | 7.6 (4.1–14.1) | 45.3 | 5.1 (3.8–6.9) |
Non-β-blocker | 20.7 | 2.1 (1.3–3.4) | 20.7 | 13.4 (6.8–26.2) | 62.2 | 10.3 (7.0–15.3) |
Both β-blocker and non-β-blocker | 28.5 | 2.7 (1.8–3.9) | 34.7 | 21.1 (11.6–38.3) | 87.5 | 41.2 (27.7–61.2) |
*Represents the rate for each perinatal outcome according to type of antihypertensive therapy **All odds ratios were adjusted for maternal age, parity, pre-pregnancy weight, history of delivery before 34 weeks, history of hypertension in a previous pregnancy, cigarette smoking, pre-pregnancy diabetes mellitus, pre-pregnancy renal dysfunction, use of prednisone, and gestational age at which blood pressure first increased above 140/90 mm Hg.