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. 2018 Jul 1;29(7):785–801. doi: 10.1089/hum.2017.151

Figure 1.

Figure 1.

Nerve conduction velocity (NCV) in normal, globoid cell leukodystrophy (GLD), and adeno-associated virus (AAV)-treated dogs. NCV was conducted on untreated GLD dogs at the defined humane endpoint (14–19 weeks of age; n = 6; solid square), normal age-matched control dogs (14–21 weeks; n = 9; solid circle), and AAV-treated GLD dogs at endpoint (AAV-GFP, n = 1, solid diamond; AAVrh10-cGALC low dose, n = 2, solid triangle; AAVrh10-cGALC high dose, n = 2, solid triangle). For pelvic limb motor NCV, the (A) tibial nerve was stimulated at the tarsus and stifle, the (B) sciatic nerve was stimulated at the stifle and at the level of the femoral head, and for the thoracic limb the (C) ulnar nerve was stimulated at the carpus and elbow, and for sensory NCV the (D) radial nerve at the level of the elbow. *p ≤ 0.05; **p ≤ 0.01.