Table 1. mRNA gene expression changes in MM-231 TNBC.
The left side of the table presents the NF-қB-controlled genes that are upregulated (+ fold-changes) by 50 ng/mL TNF-α. In contrast, the right side presents expression of genes that are downregulated (- fold-changes) by 4 μM PL. p < 0.05 is considered statistically significant.
| Control vs. TNF-α | TNF-α vs. TNF-α + PL | ||||
|---|---|---|---|---|---|
| Target gene | Fold changes | p-value | Target gene | Fold changes | p-value |
| BCL2A1 | 60.29 | < 0.0001 | BCL2A1 | -5.36 | 0.001 |
| BIRC3 | 3.05 | 0.011 | BIRC3 | -1.80 | 0.002 |
| CCL2 | 2.90 | 0.039 | CCL2 | -25.58 | 0.007 |
| ICAM1 | 6.21 | 0.006 | ICAM1 | -5.47 | 0.007 |
| IKBKE | 1.57 | 0.378 | IKBKE | -6.05 | 0.010 |
| IL1β | 11.79 | 0.003 | IL1B | -9.50 | 0.004 |
| LTA | 5.67 | 0.005 | LTA | -6.98 | 0.005 |
| TLR2 | 2.43 | 0.116 | TLR2 | -2.76 | 0.040 |
| TNF | 56.13 | < 0.0001 | TNF | -9.25 | 0.0002 |