Table 1. Characteristics of eligible 2,714 participants in the Framingham Offspring Study.
Values are represented in percentage unless otherwise indicated.
| Characteristics | 3rd exam (pre-baseline; 1984–1987) |
4th exam (baseline; 1987–1991) |
5th exam (1991–1994) |
6th exam (1994–1998) |
7th exam (1998–2001) |
|---|---|---|---|---|---|
| Current smoker | 27.5 | 23.0 | 19.1 | 14.9 | 12.2 |
| Cigarettes per day among smokers, mean (SD) | 22.9 (12.9) | 21.9 (12.6) | 21.1 (12.0) | 19.9 (11.7) | 18.3 (11.3) |
| Alcoholic drinks per day | |||||
| None | 27.6 | 29.8 | 30.2 | 36.8 | 33.7 |
| >0 to <2 | 54.2 | 55.5 | 55.3 | 53.2 | 52.9 |
| 2 to <4 | 13.9 | 11.3 | 11.7 | 8.6 | 10.8 |
| 4 or more | 4.3 | 3.4 | 2.9 | 1.4 | 2.6 |
| Body mass index (kg/m2); mean (SD) | 26 (4.6) | 26.6 (4.8) | 27.3 (4.9) | 27.8 (5.2) | 28.1 (5.3) |
| Diabetes | 2.7 | 3.9 | 6.3 | 9.6 | 12.3 |
| Systolic blood pressure (mmHg); median (IQR) | 121 (111, 132) | 124 (112, 137) | 124 (112.5, 137) | 126 (114, 138.5) | 125 (114, 138) |
| Systolic blood pressure categories | |||||
| <120 mmHg (Low) | 45.8 | 40.5 | 40.2 | 34.3 | 34.1 |
| 120 to <140 mmHg (Pre-hypertension) | 40.6 | 38.6 | 38.6 | 39.3 | 37.5 |
| 140 to <160 mmHg (Stage 1 hypertension) | 11.0 | 16.1 | 16.4 | 16.2 | 15.5 |
| ≥160 mmHg (Stage 2 hypertension) | 2.6 | 4.9 | 4.9 | 6.0 | 5.2 |
| LDL-cholesterol (mg/dL); median (IQR) | 133 (110.2, 158.6) | 130.6 (107, 156.2) | 125.4 (104.4, 148.6) | 125 (104.8, 147.8) | 119.2 (98.4, 141) |
| LDL-cholesterol categories | |||||
| <130 mg/dL (low) | 46.3 | 49.2 | 53.7 | 52.7 | 56.6 |
| 130 to <160 mg/dL (moderate) | 29.7 | 29.8 | 29.8 | 26.8 | 22.4 |
| 160 to <190 mg/dL (high) | 16.8 | 15.6 | 11.5 | 11.3 | 8.2 |
| ≥190 mg/dL (very high) | 7.2 | 5.4 | 3.8 | 3.6 | 2.1 |
| Blood pressure medication | 13.5 | 15.1 | 16.3 | 25.6 | 32.6 |
| Lipid-lowering medication | 0.7 | 2.6 | 5.7 | 10.8 | 18.7 |