Table 1. Purine metabolites in cell lysates of non-transfected (non TR) and wt transfected (TR) CR-cells (n = 3).

	HeLa	CR-PFAS		CR-PAICS		CR-ADSL		CR-ATIC
metabolite	μmol/l	non TR μmol/l	TR μmol/l	non TR μmol/l	TR μmol/l	non TR μmol/l	TR μmol/l	non TR μmol/l	TR μmol/l
FGAr	nd	12.1±2.1	0.32±0.22	0.28±0.06	nd	nd	nd	nd	nd
FGAR	nd	2.1±0.9	0.07±0.06	0.13±0.04	nd	nd	nd	nd	nd
AIr	nd	nd	nd	1.0±0.1	0.004±0.001	nd	nd	nd	nd
AIR	nd	nd	nd	2.93±0.16	0.33±0.01	nd	nd	nd	nd
SAICAr	nd	nd	nd	nd	nd	0.40±0.04	0.072±0.002	0.05±0.01	≈ LOQ
SAICAR	nd	nd	nd	nd	nd	0.21±0.03	nd	nd	nd
S-Ado	≈ LOQ	≈ LOQ	≈ LOQ	≈ LOQ	≈ LOQ	10.5±1.1	1.9±0.2	≈ LOQ	≈ LOQ
SAMP	≈ LOQ	≈ LOQ	≈ LOQ	nd	nd	22.7±2.5	nd	nd	nd
AICAr	nd	nd	nd	nd	nd	nd	nd	0.09±0.03	nd
AICAR	nd	nd	nd	nd	nd	nd	nd	1.2±0.4	nd

nd–not detected

≈ LOQ—Values close to limit of quantification.