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. 2018 Jul 18;14(7):e1006293. doi: 10.1371/journal.pcbi.1006293

Fig 17. Simulating repetitive firing as seen in bladder small DRG neuron soma during bladder inflammation.

Fig 17

(A) The AP firing in the bladder capsaicin-sensitive (or small-diameter) DRG neuron soma in bladder inflammation evoked by application of a long duration current clamp stimulus (0.12 nA, 600 ms) [10]. Stimulus resulted in generation of 12-13 APs in 600 ms (∼ 20 Hz). Compare with Fig 9B in which a long duration stimulus gave only one spike. (B) Simulating the inflammatory firing frequency in model neuron by altering the Nav 1.8, KA and KDR channel maximum conductances. (C) Temporal changes in intracellular calcium concentration,[Ca]i and (D) instantaneous SKCa conductance, g for the firing shown in (B).