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. 2018 Jun 11;293(30):11944–11954. doi: 10.1074/jbc.RA118.002568

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© 2018 Hughey et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 4. — Dysregulated energy metabolism in glycine N-methyltransferase knockout mice. A, schematic representation of select metabolites and pathways related to energy homeostasis. B, hepatic adenine purine nucleotides ATP, ADP, AMP, and TAN pool (TAN = ATP + ADP + AMP) from glycine N-methyltransferase KO and WT mice. Energy state indexes energy charge ([ATP + 0.5·ADP]/[TAN]) and ADP/ATP. C, isolated, intact hepatocyte respiratory states (routine, LEAK, and electron transport system) and flux control ratios: LEAK/routine (L/R), LEAK/electron transport system (L/E), and routine/electron transport system (R/E). D, schematic representation of select metabolites associated with NNMT-mediated transmethylation. E, NNMT-related metabolites: nicotinamide, 1-methylnicotinamide, nicotinamide mononucleotide, and NAD⁺. Data are mean ± S.E. (error bars). n = 6–9 mice/group. *, p < 0.05 versus WT.