Figure 4.

BmSTING expression affects the host defense against BmNPV virus in vivo. A, BmSTING was down-regulated by dsRNA injected into silkworm larvae (n = 10). B, the survival rate of silkworm injected with dsBmSTING or dsRFP after BmNPV infection (n = 30). Nm DZ silkworms treated with dsRNA against BmSTING were infected with BmNPV (10⁶ pfu/ml) by injection. C–E, qRT-PCR analysis of viral DNA (C), BmCecB (D), and BmGloverin mRNA (E) in BmSTING RNAi or control silkworm. The data are displayed as mean ± S.D. (error bars) for three independent experiments. *, p < 0.05; **, p < 0.01; ***, p < 0.001.