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. 2018 May 31;293(30):11809–11822. doi: 10.1074/jbc.RA117.001253

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© 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 6. — Exons A and B are important for the localization of Drp1_ABCD at lysosomes/late endosomes and the plasma membrane. A, Drp1-KO MEFs individually expressing the indicated Drp1 isoforms were analyzed by confocal immunofluorescence microscopy with antibodies to Drp1 and Lamp1. Scale bar = 20 μm. B, the indicated MEFs with specific Drp1 isoforms were analyzed by immunofluorescence microscopy using anti-Drp1 antibodies. Boxed regions are enlarged. Scale bar = 20 μm. C, Drp1-KO MEFs expressing the HA-tagged GTPase domain carrying no exon, AB exons, or full-length Drp1_ABCD were analyzed by immunofluorescence microscopy using antibodies to the HA epitope and Lamp1. D, Drp1-KO MEFs expressing Drp1_ABCD along with GFP-tagged AB exons (GFP-AB or AB-GFP) were analyzed by immunofluorescence microscopy using antibodies to Drp1 and Lamp1. Scale bar = 20 μm.