Figure 3.

High resolution crystal structure of full-length Op vinculin. A–C, comparison of Op vinculin structure (B) with previously solved structures of chicken vinculin (A) (73) and subunit B of human αE-catenin dimer (C) (75). Domain schematic of each protein is below the structure, and the domains of each protein are color-coded: 1A in light blue, 1B in dark blue, 2A and 2B in gray, 3A in light green, 3B in dark green, 4 in orange, and domain 5/actin-binding domain in red. Asterisks and arrows indicate conformational shifts of domains 3A and 5/actin-binding domain, respectively.