Table 3.
Associations {adjusted odds ratio and 95% confidence interval [OR (95% CI)]} between maternal urinary concentrations of phthalate metabolites and occurrence of eczema phenotypes in boys ().
Year, eczema | MEP | MBP | MiBP | MECPP | MEHHP | MEOHP | MEHP | MBzP | MCOP | MCPP | MCNP | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 1.69 (1.05, 2.73)* | 1.17 (0.74, 1.84) | 1.78 (0.95, 3.33)† | 1.04 (0.55, 1.98) | 1.06 (0.61, 1.85) | 1.07 (0.60, 1.92) | 1.06 (0.61, 1.83) | 1.10 (0.60, 2.00) | 1.25 (0.70, 2.20) | 1.15 (0.66, 2.00) | 0.88 (0.59, 1.32) | 1.01 (0.87, 1.18) |
2 | 1.08 (0.74, 1.57) | 1.12 (0.76, 1.63) | 1.15 (0.64, 2.09) | 0.94 (0.58, 1.52) | 0.94 (0.60, 1.46) | 0.97 (0.61, 1.54) | 0.88 (0.57, 1.36) | 1.14 (0.70, 1.87) | 0.85 (0.52, 1.37) | 1.18 (0.75, 1.87) | 0.84 (0.55, 1.29) | 0.98 (0.87, 1.10) |
3 | 1.46 (0.89, 2.40) | 1.12 (0.74, 1.69) | 1.81 (0.94, 3.49)† | 0.72 (0.38, 1.34) | 0.88 (0.50, 1.54) | 0.90 (0.50, 1.60) | 0.94 (0.61, 1.47) | 1.14 (0.70, 1.86) | 1.28 (0.79, 2.09) | 1.09 (0.64, 1.85) | 1.61 (1.00, 2.59)* | 0.96 (0.84, 1.11) |
4 | 1.03 (0.79, 1.33) | 1.15 (0.87, 1.85) | 1.68 (1.16, 2.45)* | 1.32 (0.96, 1.83)† | 1.29 (0.95, 1.74)† | 1.30 (0.95, 1.77)† | 1.21 (0.91, 1.61) | 1.24 (0.91, 1.69) | 1.37 (0.99, 1.89)† | 1.11 (0.79, 1.56) | 1.22 (0.95, 1.57) | 1.07 (0.99, 1.15)† |
5 | 1.10 (0.86, 1.42) | 1.10 (0.83, 1.47) | 1.63 (1.12, 2.36)* | 1.46 (1.04, 2.06)* | 1.32 (0.96, 1.81)† | 1.33 (0.96, 1.85)† | 1.38 (1.03, 1.85)* | 1.30 (0.96, 1.76)† | 1.60 (1.16, 2.23)* | 1.19 (0.84, 1.69) | 1.37 (1.04, 1.80)* | 1.08 (1.00, 1.18)* |
Early-onset eczema | 1.06 (0.89, 1.25) | 1.10 (0.92, 1.32) | 1.27 (1.00, 1.72)* | 1.03 (0.77, 1.36) | 1.02 (0.79, 1.32) | 1.04 (0.80, 1.36) | 1.06 (0.85, 1.32) | 1.13 (0.88, 1.47) | 1.29 (1.04, 1.60)* | 1.18 (0.93, 1.49) | 1.08 (0.90, 1.30) | 0.98 (0.92, 1.04) |
Late-onset eczema | 1.13 (0.90, 1.42) | 1.17 (0.96, 1.42) | 1.55 (1.10, 2.18)* | 1.34 (1.00, 1.81)* | 1.26 (0.96, 1.67)† | 1.28 (0.96, 1.70)† | 1.18 (0.92, 1.52) | 1.19 (0.90, 1.57) | 1.63 (1.20, 2.21)* | 1.14 (0.83, 1.57) | 1.29 (1.02, 1.64)* | 1.06 (0.99, 1.13)† |
Note: Models were adjusted for parental asthma/rhinitis/eczema, maternal smoking, maternal age, maternal BMI, maternal education level, gestational age, number of siblings, and recruitment center. Note: BMI, body mass index; CI, confidence interval; DEHP, di(2-ethylhexyl) phthalate; MBP, mono-n-butyl phthalate; MBzP, Monobenzyl phthalate; MCNP, monocarboxy-isononyl phthalate; MCOP, monocarboxy-isooctyl phthalate; MCPP, mono (3-carboxypropyl) phthalate; MECPP, mono (2-ethyl-5-carboxypentyl) phthalate; MEHHP, mono (2-ethyl-5-hydroxyhexyl) phthalate; MEHP, mono (2-ethylhexyl) phthalate; MEOHP, mono (2-ethyl-5-oxohexyl) phthalate; MEP, monoethyl phthalate; MiBP, mono-isobutyl phthalate; OR, odds ratio.
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