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. Author manuscript; available in PMC: 2018 Jul 30.
Published in final edited form as: Bioconjug Chem. 2015 May 27;26(6):1086–1094. doi: 10.1021/acs.bioconjchem.5b00144

Scheme 1. Synthesis of SDIO–DO3A Nanoparticlesa.

Scheme 1

aDMAP, 4-(dimethylamino) pyridine. In this new method, conjugation of the chelator is achieved by directly coupling to the hydroxyl groups without a requirement of cross-linking and amination. Sulfation is realized after conjugation of the chelator to maximize the sulfation degree.