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. Author manuscript; available in PMC: 2018 Jul 31.
Published in final edited form as: Int J Obes (Lond). 2018 Jan 30;43(2):344–354. doi: 10.1038/s41366-018-0013-5

Figure 4. Food and water intake after IP ghrelin challenge.

Figure 4

Food intake (mean + SEM) in GHSR KO (purple; n = 8) and WT (blue; n = 8) rats after IP injections of saline or acyl-ghrelin (3 nmol/kg or 6 nmol/kg) measured at 1 (A), 2 (B) and 6 h (C) post injection. In the WT group, both doses of ghrelin increased food consumption at the 1 h time point compared to vehicle (p < 0.05). There was no effect of IP ghrelin administration on food consumption in the GHSR KO group. Across time points, the GHSR KO group consumed less food than the WT regardless of vehicle or ghrelin treatment (p < 0.05, overall genotype effect; p < 0.05, different chow consumption from 0 nmol ghrelin (saline)). There was no effect of IP ghrelin administration on water intake at 1 (D), 2 (E) or 6 h (F) post injection, and there was no difference in water intake between the GHSR KO and WT groups. GHSR: growth hormone secretagogue receptor; IP: intraperitoneal; KO: knockout; SEM: standard error of the mean; WT: wild type.