Fig. 2. The association between GABRA2 rs279858, reward network, and cognition.

a The effect pattern of GABRA2 rs279858 on the reward network. In the HC group, the mean connective strength in rs279858*G allele carriers was significantly lower than in A allele carriers. The A allele had a dose-dependent effect on the differences in connective strength of the reward network between HAs and HCs. *p < 0.05, within genetic group difference; ^#p < 0.05, within health control group difference; BTN-connections, between reward control subnetwork and reward driving subnetwork. The data are expressed as mean ± standard deviation. b Significant positive correlation between the mean strength of Diff-connections and cognition, evaluated using MoCA. c The results of mediate analysis demonstrates the association between rs279858 and cognition was mediated by the connective strength of the reward network in the control group, but mediate association is indistinct after heroin use and addiction