Table 3.

Treatment administration

	All patients	Phase 2 dose
	(N = 48)	(N = 45)
Ixazomib
Number of cycles	620	561
Median dose (mg, Range)	12 (3–120)	12 (3–120)
Number of patients with dose reductions	6 (13%)	6 (13%)
Total number of dose reductions	8	8
Cyclophosphamide
Number of cycles	382	357
Median dose (mg, Range)	2800 (0–5000)	3000 (0–5000)
Number of patients with dose reductions	16 (33%)	16 (36%)
Total number of dose reductions	24	24
Dexamethasone
Number of cycles	386	361
Median dose (mg, range)	160 (0–160)	160 (0–160)
Number of patients with dose reductions	20 (42%)	18 (40%)
Total number of dose reductions	29	26
Treatment delays
Number of patients	14 (25%)	12 (27%)
Total number of delays	19	15