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. 2018 Jul 24;9:1642. doi: 10.3389/fimmu.2018.01642

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Copyright © 2018 Waldner, Zhang, James, Allbright, Havis, Bliley, Almadori, Schweizer, Plock, Washington, Gorantla, Solari, Marra and Rubin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ratios ranging from 4:1 to 16:1 between responder cells [peripheral blood mononuclear cells (PBMCs)] and mesenchymal stem cell (MSC) were added to proliferation assays (n = 3 from three different human donors) stimulated with phytohemagglutinin (PHA) (A). All three types of MSC show a dose depended reduction responder cell proliferation detected by H³ thymidine assay, with the most effective inhibition by adipose-derived mesenchymal stem cell (ASC). Panel (B) shows representative results of a co-culture stimulated with PHA, gated on CD3+ and CD4+ cells confirming potent inhibition by ASC. Addition of stromal vascular fraction (SVF) cells at the same ratio resulted in a far weaker inhibition compared with cultured cells (P3).