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. 2018 Jul 24;9:1642. doi: 10.3389/fimmu.2018.01642

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Copyright © 2018 Waldner, Zhang, James, Allbright, Havis, Bliley, Almadori, Schweizer, Plock, Washington, Gorantla, Solari, Marra and Rubin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Specific stimulation of responder peripheral blood mononuclear cells (PBMCs) using irradiated splenocytes from a 6/6 mismatched donor resulted in a robust stimulation in controls (n = 4, from different donors). The addition of s.c.ASCs, o.ASCs, and bone marrow-derived mesenchymal stem cells (BMSCs) resulted in a dose-dependent inhibition of responder cell proliferation (A). At all ratios tested ranging from 1:4 to 1:16 between mesenchymal stem cell (MSC) and PBMC, there was a significant inhibition compared with stimulated responders alone (p < 0.05), while there was no significant different between the different ratio steps. Analysis via carboxyfluorescein succinimidyl ester mixed lymphocyte reaction (n = 4, from different donors) demonstrated a significant inhibition of CD3+, CD4+ cells (B).