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. 2018 Jul 24;12:492. doi: 10.3389/fnins.2018.00492

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Copyright © 2018 Qian, Dou, Ruan, He, Zhang and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neuregulin1 isoformβ1 (Nrg1β1) treatment improved neurological functions, reduced brain water content and deceased albumin leakage at 24 and 72 h after SAH. Neurological impairment (A,B), increased brain water content (C,E) and albumin extravasation (D,F) were found in the SAH + Vehicle groups. Nrg1β1 (150 ng/kg) treatment significantly alleviated neurological deficit (A,B), reduced brain water content (C,E) and deceased albumin extravasation (D,F). n = 6 for each group. ^∗p < 0.05 versus sham; #p < 0.05 versus SAH + vehicle; &p < 0.05 versus SAH + Nrg1β1 (50 ng/kg).