FIGURE 2.

Common and distinct brain areas associated with the two paradigms. The common neural network activated in both picture-based and cue-based paradigms is the affective components of the pain matrix including the AI and MCC/ACC. Picture-based paradigms trigger distinct responses in somatosensory regions of pain including S1 and S2, and some brain areas for action observing, understanding and imitation including the ventral premotor cortex and the anterior inferior parietal cortex. While cue-based paradigms uniquely activate regions for mentalizing including the precuneus, temporo-parietal junction (TPJ), ventral parts of medial prefrontal cortex (mPFC), posterior superior temporal cortex, and temporal poles.