Table 1.
Pocket A residues and their respective protein locations aligned between ASCT2 and EAAT1 and GltPh-R397C.
| Location | ASCT2 | EAAT1 | GltPh-R397C |
|---|---|---|---|
| Residue | Residue | Residue | |
| TM2 | V96I(a) | V58 | |
| I100 | |||
| TM4C | A243I(b) | V151 | |
| HP1 | S352 | S364 | S277 |
| S353 | S365 | S278 | |
| S354 | S366 | S279 | |
| A355 | A367 | G280 | |
| L357 | L369 | L282 | |
| TM7 | P380 | P392 | |
| V393 | |||
| A383 | A395 | A307 | |
| T384 | T396 | T308 | |
| I397 | I309 | ||
| N398 | |||
| HP2 | S425 | S437 | |
| V426 | I438 | ||
| G427 | G439 | ||
| A428 | A440 | T352 | |
| A429 | A441 | A353 | |
| G430 | G442 | G354 | |
| I431 | I443 | V355 | |
| P432 | P444 | P356 | |
| A433 | G357 | ||
| G434 | A358 |
(a)
V96 and
(b)
A234 is mutated to I in EAAT1 crystal (5MJU).