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. 2018 Jul 24;9:910. doi: 10.3389/fphys.2018.00910

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Copyright © 2018 Moore and von Lindern.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RNA binding proteins (RBP) control mRNA stability and translation. Interaction of eIF4G in the eIF4F complex with PABP results in a closed loop model of mRNA translation (see legend Figure 2). Binding of PABPs to the poly(A) tail enhances mRNA stability and translation. A variety of RBP binding to e.g., the cytoplasmic polyadenylation element (CPE), AU-rich Elements (ARE) or other element represented as XX. These RPB interact with polyadenylases or with the CCR4/NOT deadenylating complex.