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. 2018 Jul 24;10:22. doi: 10.3389/fnsyn.2018.00022

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Copyright © 2018 Khlghatyan and Beaulieu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Integration of dopamine receptor D1-mediated signaling and glutamatergic neurotransmission by Fmr1. D1 receptor-mediated signaling results in phosphorylation of GluA1 subunits of AMPA receptors. Fmr1 regulates phosphorylation of D1 receptors via direct interaction with GRK2. This regulation of D1 by Fmr1 subsequently impacts phosphorylation of GluA1. Fmr1 also regulates trafficking of GluA1 via unknown mechanism.