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. 2018 Jul 24;10:22. doi: 10.3389/fnsyn.2018.00022

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Copyright © 2018 Khlghatyan and Beaulieu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Integration of dopamine receptor D2-mediated signaling and glutamatergic neurotransmission by Fxr1. Fxr1 regulates trafficking of GluA1, GluA2, and synthesis of GluA2 subunits of AMPA receptors. Lithium and valproate regulate Fxr1 levels downstream of D2-βArr2-Akt-Gsk3β pathway. Lithium and valproate also regulate trafficking of GluA1, suggesting possible mechanistic involvement of Fxr1. Fxr1 regulates biogenesis of schizophrenia related Mir9, which, in turn, negatively regulates translation of D2 receptors.