Table 1.

Amino acid sequence alignments of the C-terminal hypervariable region (HVR) in different Ras proteins isoforms.

The differences in amino acid sequences between mammalian Ras proteins (HRas-Hu, NRas-Hu, KRas4B-Hu) and fungal Ras1/Ras2 proteins are mainly in their C-terminal hypervariable region (HVR). Numbers at the two sides of H-Ras C-terminal indicate amino acid positions. Hu, Human; Cn, Cryptococcus neoformans; Sz, Schizosaccharomyces pombe; Sc, Saccharomyces cerevisiae.

^*The HVR-1, HVR-2 and Lipid anchor domains at the C-terminal end of H-Ras are named following Rotblat et al. (2004).