Table 5.
Toxicological studies of PSP1 applied in high doses on bee, fish, chicken and three mammalian species (rat, rabbit, and guinea pig).
| Tier testing | Tested dose or concentration | Effects | IOBC classification |
|---|---|---|---|
| Acute Dermal Irritation/Corrosion Test in rabbits | 22 μg TSP/animal | 0 | |
| Acute Eye Irritation/Corrosion in rabbits | 5 μg TSP/animal eye | 0 | |
| Acute Oral Toxicity in rats | 225 μg TSP/kg of body weight | LD50 > 225 μg TSP/kg of body weight | |
| Acute Dermal Toxicity Test in rats | 225 μg TSP/kg of body weight | LD50 > 225 μg TSP/kg of body weight | |
| Acute Inhalation Toxicity Test in rats | 0.16 μg TSP/l of air | LD50 > 0.16 μg TSP/l of air | |
| Dermal Sensitization Test in guinea pigs | 40.5 μg TSP/animal | 0 | |
| Fish Acute Toxicity | 4.5 and 0.45 μg TSP/l | LD50 > 4.5 μg TSP/l at 96 h | Practically harmless |
| Avian Acute Oral Toxicity Test | 90 μg TSP/kg of body weight | LD50 > 90 μg TSP/kg of body weight to 14 days | Practically harmless |
| Honeybees Oral Toxicity Test | 4.5 ng TSP/bee | LD50 > 4.5 ng TSP/bee at 48 h | Virtually harmless |
All toxicity tests were carried out according to OECD guidelines and IOBC standard protocols. LD50, median lethal dose.