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. 2018 Jul 24;12:218. doi: 10.3389/fncel.2018.00218

Figure 4.

Figure 4

The phasic pheromone response was increased by OAG but decreased by DOG. (A,B) The phasic pheromone response (=frequency of the first 6 bombykal (BAL)-dependent action potentials (APs)) was stable in recordings during the late activity phase (ZT 1) for controls as well as for application of 100 μM OAG. However, with OAG phasic pheromone responses were significantly elevated in comparison to the controls at the beginning- and at the end of the recordings. Infusion of 100 μM DOG significantly reduced the phasic pheromone response as compared to controls already during the first 20 min and further decreased it toward the end of the recordings. (C,D) In the first hour of recordings during the animals' resting phase (ZT 9) application of 100 μM OAG significantly increased the AP frequencies while 100 μM DOG had no effect. In the second hour of the recordings DOG continuously decreased the frequency of the first 6 BAL-dependent APs while in controls as well as with 100 μM OAG the levels were unchanged (for exact P-values see Table 3; for mean values ± SEM see S3. n.s. = not significant; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; Wilcoxon test, Mann-Whitney test or Kruskal-Wallis test with Dunn's post-hoc test for multiple comparison).