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. 2018 Jul 24;9:1618. doi: 10.3389/fimmu.2018.01618

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Copyright © 2018 Egorov, Kasatskaya, Zubov, Izraelson, Nakonechnaya, Staroverov, Angius, Cucca, Mamedov, Rosati, Franke, Shugay, Pogorelyy, Chudakov and Britanova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Properties of naïve T cell T-cell receptor (TCR) beta CDR3 repertoires and aging. Weighted (accounting for clonotype size) analysis of TCR beta repertoires properties for CD4 and CD8 naïve T cells derived from peripheral blood samples of young and old healthy donors. (A) Average CDR3 length, size of NDN insert, and count of randomly added N nucleotides. (B) Amino acid composition within 5 amino acid residues in the middle of CDR3. Our data and Qi et al. data, n = 8 young and 12 old individuals totally. CDR3 repertoires for the seven largest TRBV segments were analyzed separately, with Z-score normalization to account for TRBV-specific differences.