Table 2.

SCAP biological relevance in terms of differentiation and/or paracrine potential with references included.

SCAP differentiation potential	In vivo/in vitro	Cell secretome/ implanted cells	Factors involved		Ref
Osteogenic/ odontogenic	Both	Implanted cells	DSPP BSP ALP BGLAP BMP RUNX2		Bakopoulou et al., 2013
Adipogenic	In vitro	Implanted cells	LPL PPAR gamma2		Ding et al., 2010; Bakopoulou et al., 2013
Chondrogenic	In vitro	Implanted cells	Proteo-glycans		Cao et al., 2013
Neurogenic	Both	Cell secretome GDNF NT3 CNP Survivin NSE VEGFA BFGF	BDNF NGF GDNF GAD NeuN Nestin GFAP NCAM Neuro-filament		Sonoyama et al., 2006; Bakopoulou et al., 2013, 2015; de Almeida et al., 2014; Yuan et al., 2014; Germain et al., 2015
Angiogenic	Both	Cell secretome bFGF PDGF VEGF angiopoietin-1 MMPs Endostatin IGFBP-3 ephrinB2 HIF-1	+ uPA, EDN2 DPPIV ANG	– PAI-1 THBS1 TIMP1/4 PTX3 PGGF PAO-1	Hilkens et al., 2017 Yuan et al., 2014