Table 4.

Accuracy of circulating tumor biomarkers for gastrointestinal stromal tumor recurrence (excluding duplicate studies and those with unclear number or fewer than 20 recurrences).

Author, year	Biomarkers	Stage	Pre-op, post-op or time of recurrence	No. recurrence/total	Sensitivity for recurrence	Specificity for recurrence	NPV for recurrence	PPV for recurrence	HR for recurrence (95% CI)	Adjusted HR (95% CI)	Mean/Median recurrence-free survival
RECURRENCE
Rawnaq; 2011 (76)	12 microsatellite markers for loss of heterozygosity	Advanced or recurrent GIST	Post-op	29/83	58%	75%	N/A	N/A	N/A	N/A	N/A

CI, Confidence interval; HR, hazard ratio; N/A, not applicable; NPV, negative predictive value; PPV, positive predictive value; post-op, post-operative; pre-op: pre-operative.