Table 1.

CBD and PTSD: “from bench research…”.

References in chronological order	Animal/test(s) used	Effective dose/route of administration	Effect	Possible mechanisms of action
Bitencourt et al., 2008.	Rats/Contextual fear conditioning	CBD 2 μg/μl i.c.v.	Facilitated extinction of contextual fear memory	Via CB1 receptors
Lemos et al., 2010.	Rats/Contextual fear conditioning	CBD 10 mg/kg i.p. and CBD 30 nmol into the PL PFC.	Decreased retrieval of contextual fear memory	Not shown, but highlights the involvement of the PL PFC
Levin et al., 2012.	Rats/Contextual fear conditioning	CBD 1 mg/kg i.p.	Decreased acquisition of contextual fear memory	Not shown
Stern et al., 2012.	Rats/Contextual fear conditioning	CBD 10 mg/kg i.p.	Blockade reconsolidation of contextual fear memory	Via CB1 receptors
Do Monte et al., 2013.	Rats/Contextual fear conditioning	CBD 0.4 μg/side intra-IL cortex	Facilitated extinction of contextual fear memory	Via CB1 receptors and highlights the involvement of the IL cortex
Stern et al., 2015.	Rats/Contextual fear conditioning	CBD 1 mg/kg i.p. + THC 0.1 mg/kg i.p.	Blockade reconsolidation of contextual fear memory	Not shown
Gazarini et al., 2015.	Rats/Contextual fear conditioning	CBD 10 mg/kg i.p.	Blockade reconsolidation of contextual fear memory	Not shown

CBD, cannabidiol; i.c.v., intracerebroventricular; i.p., intraperitoneally; PL PFC, prelimbic prefrontal cortex; IL, infralimbic.