Table 2.
CBD and PTSD: “...to confirmation in human trials.”
| References in chronological order | Subjects/test(s) used | Effective dose/route of administration | Effect | Possible mechanisms of action |
|---|---|---|---|---|
| Passie et al., 2012. | 19 year-old male with PTSD (case report) | CBD + THC (cannabis resin from Turkey – 1/1 proportion)/smoked | Patient experienced reduced stress, less involvement with flashbacks and a significant decrease of anxiety. | Not shown |
| Das et al., 2013. | Healthy humans/Pavlovian fear-conditioning paradigm | CBD 32 mg inhaled | Enhanced consolidation of explicit fear extinction | Not shown |
| Greer et al., 2014. | 80 patients with PTSD | CBD + THC (cannabis – unknown proportion)/smoked | Cannabis (CBD + THC) is associated with PTSD symptom reduction. | Not shown |
| Shannon and Opila-Lehman, 2016. | 10 year-old girl with PTSD (case report) | CBD oil at least 25 mg daily for 5 months/oral capsules | Maintained decrease in anxiety and a steady improvement in the quality and quantity of the patient’s sleep. | Not shown |
CBD, cannabidiol; THC, tetrahydrocannabinol.