Fig. 2.
(a) Representative paraffin-embedded sections from the wrist below the ulna, stained with haematoxylin and eosin (scale bars 200 μm, arrows indicate regions of synovitis), (b) representative images of 3D reconstructions of hind paws using micro-CT, (c) quantification of cortical erosion in the bones of the ankle, metatarsals and phalanges in WT, TNF-tg, 11βKO, and TNF-tg11βKO mice. AU (Arbitrary units). Values are expressed as mean ± standard error of six animals per group. Statistical significance was determined using one way ANOVA with a Tukey post hoc analysis. *p < 0.05, **p < 0.005, ***p < 0.001.