Table 1.
Action modes of some DNA-specific agents.
| DNA specific agent | DNA affinity/sequence specificity/action mode | Reference |
|---|---|---|
| Mithramycin | GC-rich seq.- displaces Sp1 transcription factor, minor groove binding | Barcelo et al., 2010 |
| Ethidium bromide | DNA intercalator | Lenglet and David-Cordonnier, 2010 |
| Acrid. orange | DNA intercalator, DNA single strand binder | Lenglet and David-Cordonnier, 2010 |
| Chitosan | Chitosan heptamer fits in DNA minor groove | Hadwiger and Beckman, 1980 |
| Distamycin A | Inhibitor of helicase and topoisomerase I-II, minor groove binder, stimulates Pol II pause site | Varqiu et al., 2008; Nelson et al., 2007 |
| Neomycin | Stabilizes DNA triplex TAT | Willis and Arya, 2006 |
| Daunomycin | Intercalates Adj.G/C bp on 5’side of A/T bp; Induces DNA unwind; Evicts histone from minor groove | Quigley et al., 1980 |
| Spermine | A-DNA backbone bridging major and minor grooves | Bryson and Greenall, 2000 |
| Hoechst 33258 | AT tract-topoisomerase poison; DNA minor groove binding and intercalates DNA bases | Miskovic et al., 2013 |
| DAPI | AT-specific; minor groove binding; not topo I poison | Miskovic et al., 2013 |