Table 3.
Transcript expression of microglia markers and immune modulators.
| mRNA counts | Fold change with respect to Control | ||
|---|---|---|---|
| Gene | Control | LPS | I+T |
| Ager (RAGE) | 2 ± 1 | 5.99 ± 2.13↑↑** | 0.84 ± 0.35 |
| Aif (Iba1) | 16513 ± 2476 | 3.10 ± 0.50↑↑↑*** | 1.78 ± 0.26↑↑↑ |
| Ccr2 | 6 ± 4 | 7.00 ± 3.82↑↑↑*** | 1.05 ± 0.45 |
| Ccr5 | 1987 ± 471 | 0.52 ± 0.25↓ | 2.33 ± 0.27↑↑*** |
| Cd68 (ED1) | 29185 ± 5270 | 0.89 ± 0.15 | 0.64 ± 0.07↓↓* |
| Csf1r | 18281 ± 1544 | 0.66 ± 0.18↓↓*** | 1.10 ± 0.07 |
| Cx3cr1 | 754 ± 284 | 0.12 ± 0.06↓↓↓ | 0.03 ± 0.01↓↓↓*** |
| Itgam (CD11b) | 4080 ± 994 | 4.17 ± 0.62↑↑↑*** | 1.21 ± 0.12 |
| Kdm6b (JMJD3) | 213 ± 39 | 7.87 ± 1.31↑↑↑*** | 2.90 ± 0.24↑↑↑ |
| Nfkbia (Ikba) | 3759 ± 1524 | 14.55 ± 3.17↑↑↑** | 5.99 ± 0.40↑↑↑ |
| Nr3c1 (GR) | 955 ± 101 | 2.16 ± 0.38↑↑↑ | 3.87 ± 0.41↑↑↑*** |
| Prkaa1 (AMPK) | 389 ± 65 | 3.48 ± 0.62↑↑↑*** | 1.29 ± 0.18 |
| Socs1 | 11 ± 5 | 17.90 ± 3.12↑↑↑ | 121.09 ± 34.67↑↑↑*** |
| Socs3 | 38 ± 20 | 226.86 ± 52.43↑↑↑*** | 12.09 ± 4.61↑↑↑ |
| Sparc | 3429 ± 1405 | 0.26 ± 0.06↓↓↓ | 0.21 ± 0.08↓↓↓ |
| Tlr2 | 2206 ± 798 | 5.30 ± 0.80↑↑↑*** | 1.30 ± 0.32 |
| Tlr4 | 433 ± 75 | 1.31 ± 0.24 | 0.66 ± 0.16↓*** |
| Trem1 | 131 ± 95 | 47.70 ± 17.13↑↑↑*** | 1.36 ± 0.36 |
| Trem2 | 3812 ± 713 | 0.38 ± 0.09↓↓↓ | 0.05 ± 0.02↓↓↓*** |
| Tspo | 1401 ± 616 | 4.41 ± 1.24↑↑↑ | 3.10 ± 0.54↑↑↑ |
Treatments, data presentation and analysis are as in Table 1.