Table 4.
Transcript expression of genes related to microglia physiological functions.
| mRNA counts | Fold change with respect to Control | ||
|---|---|---|---|
| Gene | Control | LPS | I+T |
| Adora1 (A1) | 3 ± 3 | 52.05 ± 10.24↑↑↑*** | 2.56 ± 1.35↑ |
| Adora2a (A2A) | 26 ± 23 | 54.90 ± 11.80↑↑↑ | 22.56 ± 2.51↑↑↑ |
| Axl | 7177 ± 1053 | 0.27 ± 0.08↓↓↓ | 0.29 ± 0.08↓↓↓ |
| Cybb (NOX2) | 2216 ± 359 | 1.12 ± 0.45 | 2.08 ± 0.29↑↑** |
| Fcgr1a (CD64) | 3866 ± 1296 | 3.16 ± 0.95↑↑↑*** | 0.46 ± 0.06↓↓ |
| Fcgr2b (CD32B) | 3480 ± 839 | 4.74 ± 1.11↑↑↑*** | 0.80 ± 0.33 |
| Fcgr3a (CD16A) | 5141 ± 2689 | 3.87 ± 1.08↑↑↑ | 4.12 ± 0.56↑↑↑ |
| Havcr2 (TIM-3) | 185 ± 23 | 28.11 ± 12.41↑↑↑*** | 3.29 ± 0.73↑↑↑ |
| Hvcn1 (Hv1) | 1469 ± 183 | 1.27 ± 0.31 | 2.81 ± 0.35↑↑↑*** |
| Itgb2 | 5351 ± 456 | 3.17 ± 0.46↑↑↑*** | 0.62 ± 0.08↓↓↓ |
| Msr1 (SR-A, CD204) | 4287 ± 844 | 5.94 ± 0.91↑↑↑*** | 0.12 ± 0.03↓↓↓ |
| Ncf1 (p47phox) | 5592 ± 1618 | 5.43 ± 0.72↑↑↑ | 6.27 ± 1.34↑↑↑ |
| Nox1 | 9 ± 3 | 1.76 ± 0.97 | 0.53 ± 0.39 |
| Nox4 | 1 ± 0.4 | 15.84 ± 6.00↑↑↑*** | 3.14 ± 2.02↑ |
| P2rx7 | 140 ± 67 | 0.32 ± 0.19↓↓** | 1.17 ± 0.55 |
| P2ry2 | 43 ± 8 | 15.58 ± 2.35↑↑↑*** | 4.62 ± 1.24↑↑↑ |
| P2ry6 | 640 ± 270 | 5.43 ± 0.65↑↑↑*** | 0.70 ± 0.16 |
| P2ry12 | 265 ± 39 | 0.19 ± 0.16↓↓↓** | 0.40 ± 0.09↓ |
| Sirpa | 4425 ± 678 | 0.81 ± 0.17 | 0.51 ± 0.03↓↓↓** |
Treatments, data presentation and analysis are as in Table 1.