Table 4. TNF-α genotype and allelic frequencies in AgP, CP, and HC group.
| Alleles and genotyping | AgP N=40 (%) | CP N=157 (%) | HC N=200 (%) | Odds ratio | 95% CI | P value | Chi square (Pearson P value) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AgP vs HC | CP vs HC | AgP vs HC | CP vs HC | AgP vs HC | CP vs HC | AgP vs HC | CP vs HC | ||||
| rs361525 -238G >A | |||||||||||
| GG | 26 | 86 | 125 | ||||||||
| GA | 12 | 47 | 44 | 1.31 | 1.55 | 0.609–2.819 | 0.947–2.545 | 0.306 | 0.053 | 0.48 (0.488) | 3.06 (0.081) |
| AA | 2 | 24 | 31 | 0.31 | 1.13 | 0.069–1.377 | 0.617–2.049 | 0.081 | 0.406 | 2.61 (0.106) | 0.15 (0.698) |
| A allele carriage | 14 | 71 | 75 | 0.89 | 1.37 | 0.441–1.825 | 0.899–2.104 | 0.456 | 0.086 | 0.09 (0.764) | 2.17 (0.14) |
| G | 64 | 219 | 294 | ||||||||
| A | 16 | 95 | 95 | 0.69 | 1.2 | 0.384–1.252 | 0.867–1.669 | 0.139 | 0.153 | 0.49 (0.222) | 1.23 (0.267) |
| rs1800629 -308G>A | |||||||||||
| GG | 10 | 40 | 101 | ||||||||
| GA | 15 | 56 | 55 | 2.75 | 2.57 | 1.16–6.54 | 1.525–4.333 | <0.01* | <0.001* | 5.56 (0.018) | 12.84 (<0.001) |
| AA | 15 | 61 | 44 | 3.44 | 3.51 | 1.43–8.26 | 2.054–5.966 | <0.001* | <0.001* | 8.28 (<0.001) | 21.98 (<0.001) |
| A allele carriage | 30 | 117 | 99 | 3.06 | 2.98 | 1.42–6.59 | 1.896–4.696 | 0.002 * | <0.001* | 8.72 (0.003) | 23.05 (<0.0001) |
| G | 35 | 136 | 257 | . | |||||||
| A | 45 | 178 | 143 | 2.31 | 2.35 | 1.42–3.761 | 1.737–3.183 | <0.0001* | <0.0001* | 11.76 (<0.0001) | 31.16 (<0.0001) |
| rs1799724 -857C>T | |||||||||||
| CC | 21 | 55 | 97 | ||||||||
| CT | 16 | 84 | 81 | 0.912 | 1.83 | 0.446–1.863 | 1.166–2.869 | 0.473 | 0.009* | 0.06 (0.806) | 6.97 (0.008) |
| TT | 3 | 18 | 22 | 0.629 | 1.44 | 0.173–2.301 | 0.712–2.921 | 0.355 | 0.2001 | 0.49 (0.481) | 1.04 (0.307) |
| T allele carriage | 19 | 102 | 103 | 0.852 | 1.75 | 0.431–1.68 | 1.13–2.68 | 0.386 | 0.007 * | 0.21 (0.646) | 6.53 (0.0106) |
| C | 58 | 194 | 275 | ||||||||
| T | 22 | 120 | 125 | 0.83 | 1.36 | 0.489–1.423 | 0.997–1.856 | 0.301 | 0.03* | 0.44 (0.507) | 3.79 (0.052) |
| rs1800630 -863C>A | |||||||||||
| CC | 17 | 84 | 104 | ||||||||
| CA | 19 | 58 | 66 | 1.76 | 1.08 | 0.854–3.63 | 0.69–1.715 | 0.087 | 0.402 | 2.39 (0.122) | 0.13 (0.718) |
| AA | 4 | 15 | 30 | 0.85 | 0.62 | 0.255–2.608 | 0.312–1.225 | 0.491 | 0.111 | 0.12 (0.731) | 1.91 (0.166) |
| A allele carriage | 23 | 73 | 96 | 1.46 | 0.94 | 0.738–2.909 | 0.619–1.431 | 0.177 | 0.43 | 1.2 (0.273) | 0.08 (0.777) |
| C | 53 | 226 | 274 | ||||||||
| A | 27 | 88 | 126 | 1.12 | 0.85 | 0.666–1.843 | 0.612–1.171 | 0.392 | 0.177 | 0.16 (0.689) | 1.01 (0.315) |
| rs1799964 -1031T>C | |||||||||||
| TT | 13 | 38 | 88 | ||||||||
| TC | 21 | 57 | 47 | 3.02 | 2.81 | 1.391–6.578 | 1.633–4.83 | 0.004* | <0.0001* | 8.2 (0.004) | 14.28 (<0.0001) |
| CC | 6 | 62 | 65 | 0.63 | 2.2 | 0.225–1.731 | 1.319–3.699 | 0.256 | 0.001* | 0.83 (0.362) | 9.21 (0.002) |
| C allele carriage | 27 | 119 | 112 | 1.63 | 2.46 | 0.795–3.346 | 1.553–3.896 | 0.12 | <0.0001* | 1.81 (0.178) | 15.09 (<0.0001) |
| C | 47 | 133 | 223 | ||||||||
| T | 33 | 181 | 177 | 0.88 | 1.71 | 0.543–1.439 | 1.272–2.311 | 0.357 | <0.0001* | 0.24 (0.624) | 12.62 (0.0003) |
*
Statistically significant (P<0.05).