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. 2018 Mar 27;153:101–113. doi: 10.1016/j.antiviral.2018.03.009

Fig. 8.

Fig. 8

R1479, 2′F-4′N3-C, and 2′diF-4′N3-C inhibit Marburgvirus Ravn virus (RAVV). (a) Representative dose-response curves of R1479 (green circles), 2′F-4′N3-C (blue triangles), and 2′diF-4′N3-C (red squares) against RAVV using an FFU assay. FFU assays were independently repeated four times for R1479, twice for 2′F-4′N3-C, and three times for 2′diF-4′N3-C. Dose response curves were fitted to the mean value of experiments performed in quadruplicate for each concentration in the 10-point, 3-fold dilution series using a 4-parameter non-linear logistic regression curve with variable slope. (b) Reduction of infectious RAVV yield (in log scale) by R1479, 2′diF-4′N3-C, and 2′F-4′N3-C. TCID50/mL values for each data point represent the mean of quadruplicate infections for each concentration in the 10-point, 3-fold dilution series of each compound performed once.