Table 2.

Mean antiviral activity of R1479, 2′F-4′N₃-C, and 2′diF-4′N₃-C in primary human small airway epithelial cells.

Family	Virus	Species/Variant	Assay	EC50 (μM) [SI]
				R1479	2′diF-4′N3-C	2′F-4′N3-C
Paramyxoviridae	NiV	Rec. M-GFP2AM	REP	>50 [ND]	2.61 [>19]	0.34 [>147]
			CPE	>50 [ND]	7.09 [>7]	0.56 [>89]
Filoviridae	MARV	Rec. Bat371-ZsG	FFU	>50 [ND]	3.59 ± 0.32 [>13]	>50 [ND]

EC₅₀, 50% effective inhibition concentration; SI, selective index = EC₅₀/CC₅₀; REP, reporter; CPE, cytopathic effect; FFU, focus-forming unit; ND, not determined; Rec, recombinant. Mean values with ±standard deviation values were derived from a minimum of 2 independent experiments performed in biological quadruplicate.