Table 2a.
SCCmec-associated patterns observed in, or derived from sequences of, CC239-MRSA assigned to the “Eurasian” (EA), “European” (EU), “Australian/NZ” (AU/NZ) Clades, to the “unassigned Middle Eastern Strain“ (ME), or to the atypical cluster of “South-East Asian Clade” isolates (S2, DEN907; SEA).
| SCCmec subtype | Reference sequence | mecA allele | mec complex | Heavy metal resistance genes | Other payload | Recombinase genes | SCC termini | nsaB status | Clade |
|---|---|---|---|---|---|---|---|---|---|
| SCC [mec III+Cd+ccrC] (T0131) | T0131, CP002643.1 | mecA(BA000018) | mecA, ugpQ, mecR1, Δ mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1, mvaS-SCC | cadD(R35) | D1GU38, Q933A2 | ccrA+B-3, ccr(AA)+C(PM1) | dcs, SCCterm02 | Insertion | EA |
| SCC [mec III+As/Cd+ccrC] (Unknown, ST239−1) | N/A | mecA(BA000018) | mecA, ugpQ, mecR1, Δ mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1, mvaS-SCC | cadD(R35), arsC-SCC | D1GU38, Q933A2 | ccrA+B-3, ccr(AA)+C | dcs, SCCterm02 | N/A | EA |
| SCC [mec III+Cd+ccrC] (CN79) | CN79, ANCJ | mecA(BA000018) | mecA, ugpQ, mecR1, Δ mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1, mvaS-SCC | cadD(R35) | D1GU38, D1GU55, Q933A2 | ccrA+B-3, ccr(AA)+C(PM1) | dcs, SCCterm02 | Insertion | EA |
| SCC [mec III+Cd+ccrC] (IU17) | IU17, CTXB | mecA(BA000018) | mecA, ugpQ, mecR1, Δ mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1, mvaS-SCC | cadD(R35) | D1GU38, D1GU55, Q933A2 | ccrA+B-3, ccr(AA)+C(PM1) | SCCterm02 | Insertion | EA |
| SCC [mec III+As/Cd+ccrC] (Unknown, ST239−2) | N/A | mecA(BA000018) | mecA, ugpQ, mecR1, Δ mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1, mvaS-SCC | cadD(R35), arsC-SCC | D1GU38, D1GU55, Q933A2 | ccrA+B-3, ccr(AA)+C | dcs, SCCterm02 | N/A | EA |
| SCC [mec III+Cd+ccrC] (Unknown, ST239−1) | N/A | mecA(BA000018) | mecA, ugpQ, mecR1, Δ mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1, mvaS-SCC | cadD(R35) | Q933A2, Q93IB7 | ccrA+B-3, ccr(AA)+C | SCCterm01 | N/A | ME |
| SCC [mec III+Cd+ccrC] (Unknown, ST239−2) | N/A | mecA(BA000018) | mecA, ugpQ, mecR1, Δ mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1, mvaS-SCC | cadD(R35) | D1GU38, D1GU55, Q4LAG7, Q933A2, Q9S0M4 | ccrA+B-3, ccr(AA)+C | dcs, SCCterm02, SCCterm05 | N/A | EA |
| SCC [mec III+Cd+ccrC] (Unknown, ST239−3) | N/A | mecA(BA000018) | mecA, ugpQ, mecR1, Δ mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1, mvaS-SCC | cadD(R35) | D1GU55, Q4LAG7, Q933A2, Q9S0M4 | ccrA+B-3, ccr(AA)+C | dcs, SCCterm05 | N/A | EA |
| SCC [mec III+ ACME II+Cd+ccrC] (Unknown, ST239) | N/A | mecA(BA000018) | mecA, ugpQ, mecR1, Δ mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1, mvaS-SCC | cadD(R35) | D1GU38, D1GU55, Q933A2, Q9S0M4, arc-genes | ccrA+B-3, ccr(AA)+C | dcs, SCCterm02, SCCterm03, SCCterm05 | N/A | EA |
| SCC [mec III+Cd+ccrC] (TUR1) | TUR1, SAMEA 1029552 | mecA(CP000046) | mecA, ugpQ, mecR1, Δ mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1, mvaS-SCC | cadD(R35) | D1GU38, D1GU55, Q933A2, Q93IB7 | ccrA+B-3, ccr(AA)+C(PM1) | SCCterm01, SCCterm02 | Insertion | EA |
| SCC [mec III+Cd/Hg+ccrC] (SK1585) | SK1585, KL662257.1 | mecA(CP000046) | mecA, ugpQ, mecR1, Δ mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1, mvaS-SCC | mer-operon, cadD(R35) | D1GU38, D1GU55, Q933A2, Q93IB7 | ccrA+B-3, ccr(AA)+C(PM1) | SCCterm01, SCCterm02 | Wild type | EU |
| SCC [mec III (Δ mecR1-)+Cd/Hg+ccrC] (BK2421) | BK2421, SAMEA 1029510 | mecA(CP000046) | mecA, ugpQ, mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1 | mer-operon, cadD(R35) | D1GU38, D1GU55, Q933A2, Q93IB7 | ccrA+B-3, ccr(AA)+C(PM1) | SCCterm01, SCCterm02 | Wild type | EU |
| SCC [mec III (Δ mecR1-)+Cd/Hg+ccrC] (85/2082) | 85/2082, AB037671.1 | mecA(CP000046) | mecA, ugpQ, mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1, mvaS-SCC | mer-operon, cadD(R35) | D1GU38, D1GU55, Q933A2, Q93IB7 | ccrA+B-3, ccr(AA)+C(PM1) | SCCterm01, SCCterm02 | Wild type | EU |
| SCC [mec III+Cd] (JKD6008) | JKD6008, CP002120.1 | mecA(BA000018) | mecA, ugpQ, mecR1, Δ mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1, mvaS-SCC | cadD(R35) | Q933A2 | ccrA+B-3 | dcs | Wild type | AU/NZ |
| SCC [mec III+ ACME II+Cd] (Unknown, ST239−1) | N/A | mecA(BA000018) | mecA, ugpQ, mecR1, Δ mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1, mvaS-SCC | cadD(R35) | Q933A2, Q9S0M4, arc-genes | ccrA+B-3 | dcs, SCCterm03, SCCterm05 | N/A | AU/NZ |
| SCC [mec III+Cd] (S2) | S2, SAMEA 1029563 | mecA(CP000046) | mecA, ugpQ, mecR1, Δ mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1 | cadD(R35) | Q933A2 | ccrA+B-3 | dcs | N/A | SEA |
| M116, GenBank CTXQ | mecA(BA000018) | mecA, ugpQ, mecR1, Δ mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1 | cadD(R35) | Q933A2 | ccrA+B-3 | dcs | SEA | ||
| SCC [mec III+Cd/Hg] (DEN907) | DEN907, SAMEA 1029548 | mecA(CP000046) | mecA, ugpQ, mecR1, Δ mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1 | mer-operon, cadD(R35) | Q933A2 | ccrA+B-3 | dcs | Wild type | SEA |
| SCCmec III (KM1381), for comparison | KM1381, AM904732.1 | mecA(BA000018) | mecA, ugpQ, mecR1, Δ mecR1, mecI, PSM-mec, xylR/mecR2, cstB-SCC1, mvaS-SCC | N/A | Q933A2 | ccrA+B-3 | dcs | N/A | pseudint. |
The predicted pattern for S. pseudintermedius, KM1381 is provided for comparison. Bold font of element designations indicates those elements that were found in study isolates.