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. 2018 Feb 19;111(8):412–423. doi: 10.1080/20477724.2018.1438880

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 2. — Population suppression versus population replacement. In both cases the modified insects are released at a low initial frequency and spread in the population over generations. The modification can be designed to interfere with the mosquito reproduction or viability, aiming to the eliminate or suppress the population to levels that do not support disease transmission (left panel). Alternatively, the modification can be engineered to replace the vector population with insects unable to effectively transmit disease (right panel).