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Aβ1-42 induced memory impairment in the step-down passive avoidance test at 1 week, 2 and 6 months after intracerebroventricular microinjection of Aβ1-42. Retention tests were conducted 3 (A) and 24 h (B) after the training session. Values shown are means ± SEM, n = 10; *p < 0.05 and ***p < 0.001 vs. vehicle-treated control group.
