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. 2018 Jul 24;10:204. doi: 10.3389/fnagi.2018.00204

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Copyright © 2018 Xu, Zhu, Xu, Ye, Liu, Wu, Zhang, Ding, Zhang, Zhang, O'Donnell and Pan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of rolipram on Aβ1-42-induced memory impairment in the Morris water-maze test in mice. One and a half months after microinfusion with Aβ1-42 into cerebroventricle, mice were administrated with rolipram for 14 days. H89 and KT5823 were pretreated 30 min before rolipram administration every day. During the acquisition trials of the water maze task, learning curve was tested 24 h after last treatment with rolipram (A,B). The probe trial was conducted 1 and 24 h after training, the latency to reach the platform (C,E) and the number of platform crossings (D,F) were determined. Values shown are means ± SEM, n = 10; ^**p < 0.01 and ^***p < 0.001 vs. vehicle treated sham group. ^#p < 0.05, ^##p < 0.01, and ^###p < 0.001 vs. vehicle-treated Aβ group. ^$$P < 0.01 and ^$$$P < 0.001 vs. rolipram (1.0 mg/kg)-treated Aβ group.