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. 2018 Jul 24;10:204. doi: 10.3389/fnagi.2018.00204

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Copyright © 2018 Xu, Zhu, Xu, Ye, Liu, Wu, Zhang, Ding, Zhang, Zhang, O'Donnell and Pan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of rolipram on 3-h (A) and 24-h (B) memory retention in the step-down passive avoidance test in Aβ42-treated mice. Aβ42-induced decreases in 3-h and 24-h retention were reversed by chronic treatment with rolipram for 14 days Values shown are means ± SEM, n = 10; ^***p < 0.001 vs. vehicle-treated control group. ^###p < 0.001 vs. vehicle-treated Aβ group. ^$$$p < 0.001 vs. rolipram (1.0 mg/kg)-treated Aβ group.