Table 2.
Correlation between MICs of SCN and N-SCN and levels of MsTopoI.
| MICs (μM) |
|||||
|---|---|---|---|---|---|
| M. smegmatis strain | Levels of TopoI | Imipramine | N-SCN | SCN | Boldine |
| mc2155 | +++ | 125–200 | 100 | 30–60 | >300 |
| MsPptrtopoI | ++ | 175–300 | 50 | 15–30 | >300 |
| MsPptrtopoI + ATc | + | 350 | 25 | 15 | >300 |
ATc, anhydrotetracycline was added at a concentration of 200 ng/ml. Topoisomerase I levels in M. smegmatis strains: +++: wild type levels; ++: 1.5 times below wild type levels; +: 2.5 times below MsPptrtopoI levels. Estimations according to Ahmed et al. (2015).