Table 1.
Comparison of disorder-specific and individually tailored treatments
| Estimated marginal means | Benchmarking parameters, percentage change and response rates | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Condition (scale) and group | n | Pre-treatment (s.d.) | Post-treatment (s.d.) | G × T, Wχ2 | G × T, P | Effect size, d (95% CI) (within group) | d – Δ | Percentage change (95% CI) | >50% response (95% CI) | Response, Wχ2 | Response, P |
| Depression (MADRS-S) | |||||||||||
| DS-depression | 2358 | 23.57 (5.76) | 13.81 (8.43) | 0.00 | 1.35 (1.29–1.42) | 41.3 (39.7–42.8) | 43.5 (41.4–45.7) | 0.51 | |||
| TAIL-depression | 284 | 22.98 (5.90) | 13.50 (8.19) | 0.98 | 1.33 (1.14–1.52) | 1.11 | 41.3 (36.7–45.6) | 45.9 (39.8–52.2) | 0.47 | ||
| Panic (PDSS-SR) | |||||||||||
| DS-panic | 1176 | 12.30 (4.30) | 5.56 (4.77) | 3.52 | 1.47 (1.37–1.56) | 54.5 (52.0–56.9) | 61.9 (58.8–64.9) | 1.02 | |||
| TAIL-panic | 54 | 12.02 (4.46) | 6.67 (5.20) | 0.06 | 1.11 (0.66–1.56) | 1.23 | 43.9 (29.0–55.6) | 53.8 (38.3–68.6) | 0.31 | ||
| Social anxiety (LSAS-SR) | |||||||||||
| DS-social anxiety | 1335 | 73.15 (22.67) | 53.79 (25.35) | 0.22 | 0.81 (0.73–0.90) | 26.5 (24.5–28.5) | 18.3 (16.2–20.7) | 0.01 | |||
| TAIL-social anxiety | 46 | 70.50 (23.25) | 53.45 (23.66) | 0.64 | 0.74 (0.27–1.21) | 0.57 | 24.2 (12.8–34.1) | 17.6 (8.1–34.1) | 0.92 | ||
DS, disorder-specific treatment; TAIL, individually tailored treatment; G × T, interaction effect of group and time from generalised estimating equations; Wχ2, Wald chi-squared; d, Cohen's d; d – Δ, non-inferiority margin; MADRS-S, Montgomery–Åsberg Depression Rating Scale – Self-rated; PDSS-SR, Panic Disorder Severity Scale – Self report; LSAS-SR, Liebowitz Social Anxiety Scale – Self-Rated.