Table 3.

Association of alcohol consumption trajectories between 1985/88 and 2002/04 with risk of dementia

Alcohol consumption trajectories	No of cases/total No	Hazard ratio (95% CI)
		Adjusted for socio-demographic variables†	Additionally adjusted for behavioural factors‡	Fully adjusted§
Cases=396/8927, mean follow-up 12.9 (SD 2.7) years
Long term abstinence	74/837	1.74 (1.31 to 2.30)*	1.73 (1.30 to 2.29)*	1.67 (1.26 to 2.23)*
Decreased consumption	36/500	1.55 (1.08 to 2.22)*	1.53 (1.07 to 2.20)*	1.50 (1.04 to 2.16)*
Long term consumption 1-14 units/week	207/5304	1 (ref)	1 (ref)	1 (ref)
Increased consumption	28/1004	0.88 (0.59 to 1.31)	0.87 (0.59 to 1.30)	0.85 (0.57 to 1.26)
Long term consumption >14 units/week	51/1282	1.40 (1.02 to 1.93)*	1.39 (1.01 to 1.92)*	1.36 (0.99 to 1.88)

^*P<0.05.

^†Adjusted for age (time-scale), sex, ethnicity, education, occupational position, and marital status.

^‡Additionally adjusted for physical activity, smoking status, and fruit and vegetable consumption.

^§Additionally adjusted for systolic blood pressure, total cholesterol, diabetes, body mass index, general health questionnaire score, cardiovascular disease, and cardiovascular disease drugs.