Figure 1.

USP8 is upregulated in PTC tissues. Protein expression levels of USP8 in paraffined cervical tissues (A) and CSCC tissues (B) were measured by IHC, showing the positive immunoreactivity in the cytoplasm of tumor cells. (C) The mean IHC staining score of CSCC tissues were analyzed based on different FIGO stages. Patients with FIGO stage III showed significant higher levels of USP8 protein than those with stage I–II (P=0.023). (D) The mRNA levels of USP8 from 27 freshly-resected CSCC tissues and paired adjacent cervical tissues were analyzed by RT-qPCR normalized with GAPDH-mRNA level, indicating that USP8 was upregulated in tumor tissues (P=0.010).