Table 1.
Key Encoded Proteins that Are Highly Involved in Mediating Pathway Activity in MRUCD200/CD200R1 and MRUnot CD200/CD200R1 Populations
| Key Proteins | Pathways |
|---|---|
| Key proteins highly expressed in MRUCD200/CD200R1 populationa | highly active pathways in MRUCD200/CD200R1 populationa |
| Complement (C1q, C3, C3a, C3b, C4b, C6) | complement pathway |
| Key proteins highly expressed in MRUnot CD200/CD200R1 populationb | highly active pathways in MRUCD200/CD200R1 populationa |
| vWF | coagulation system |
| IL6 | TREM1 signaling |
| MAGI | pTEN signaling |
| Key proteins highly expressed in MRUnot CD200/CD200R1 populationb | highly active pathways in MRUnot CD200/CD200R1 populationb |
| PI3 kinase | eNOS signaling; nitric oxide signaling; IL-8 signaling; Tec signaling; Gαq signaling; inhibition of angiogenesis by TSP1; endothelin-1 singling; anti-proliferative role of somatostatin receptor 2; thrombin signaling; HMGB1 signaling; p70s6k signaling; integrin signaling; hepatocyte growth factor (HGF) signaling |
| ERK 1/2 | nitric oxide signaling; IL-8 signaling; antiproliferative role of somatostatin receptor 2; vascular endothelial growth factor (VEGF) family of ligand receptor interactions; HMGB1 signaling; prolactin signaling; agrin interactions; Stat3 signaling; nuclear factor (NF)-κB signaling; thrombin signaling; acute-phase response signaling; CAMP-mediated signaling; chemokine signaling; Rho signaling; role of NFAT in cardiac hypertrophy; renin-angiotensin signaling; HGF signaling; mouse embryonic stem cell pluripotency |
| p38 MAPK | inhibition of angiogenesis by TSP1; thrombin signaling; acute-phase response; type 1 diabetes; HMGB1 signaling; iNOS signaling; chemokine signaling; IL-1 signaling; VEGF signaling; TGFβ signaling; mouse embryonic stem cell pluripotency |
| PKC | nitric oxide signaling; IL-8 signaling; eNOS signaling; Inhibition of angiogenesis by TSP1; p70s6k signaling |
| Gα | Tec kinase signaling; endothelin 1 signaling; signaling by Rho family GTPases; IL-1 signaling |
| Gβ | Tec kinase signaling; IL-8 signaling; Gαq signaling; cardiac β-adrenergic signaling; antiproliferative role of somatostatin receptor 2; thrombin signaling; role of NA in cardiac hypertrophy; signaling by Rho family GTPases; α-adrenergic signaling; IL-1 signaling |
| GƳ | Tec kinase signaling; IL-8 signaling; Gαq signaling; cardiac β-adrenergic signaling; antiproliferative role of somatostatin receptor 2; thrombin signaling; role of NA in cardiac hypertrophy; signaling by Rho family GTPases; α-adrenergic signaling; IL-1 signaling |
| RAS | phospholipase signaling; thrombin signaling; acute-phase response; NF-κB signaling; integrin signaling; antiproliferative role of somatostatin receptor 2; thrombin signaling; glioma invasiveness phospholipase signaling; thrombin signaling; acute-phase response; NF-κB signaling; integrin signaling; HMGB1 signaling; agrin interactions; P70S6K signaling; α-adrenergic signaling; NRF-mediated stress response; prolactin signaling; p21 activated kinase (PAK) signaling |
| IκB | Gαq signaling; acute-phase response signaling; type 1 diabetes; iNOS signaling |
| JNK | IL-8 signaling; Tec signaling; inhibition of angiogenesis by TSP1; HMGB1 signaling; type 1 diabetes; Rho signaling; IL-1 signaling; PAK signaling; HGF signaling |
| FAK | glioma invasiveness; IL-8 signaling; Tec signaling; agrin interactions; Rho signaling; chemokine signaling; integrin signaling |
| RHO | glioma invasiveness; HMGB1 signaling; IL-8 signaling; Gαq signaling |
| VEGF and receptors 1/2/3/C | nitric oxide signaling; IL-8 signaling; VEGF signaling |
| CAVEOLIN-1 | nitric oxide signaling; eNOS signaling; integrin signaling |
| eNOS | eNOS signaling; nitric oxide signaling; VEGF signaling |
| P21CIP1 | HGF pathway |
| Key proteins highly expressed in MRU CD200/CD200R1 populationa | highly active pathways in MRUnot CD200/CD200R1 populationb |
| SRC | IL-8 pathway; antiproliferative role of somatostatin receptor 2; thrombin pathway; agrin interactions; Stat3 pathway; integrin pathway; cAMP-mediated signaling; endothelin 1 signaling; phospholipase C signaling; role of NA in cardiac hypertrophy; p70s6k signaling; integrin signaling; VEGF signaling; Gα12-13 signaling |
| BTK | Gαq signaling; phospholipase C signaling; NF-κB/PI3K signaling; p70s6k signaling; Gα12-13 signaling |
| PKC | VEGF signaling |
| SHIP | NF-κB/PI3K signaling |
See also Figures S1 and S2.
Divergent pathway activity in the MRU subpopulations was determined by IPA.
a
Corresponds to MRU separation presented in Figure 1: MRUCD200/CD200R1 expresses high levels of both CD200 and CD200R1.
b
Corresponds to MRU separation presented in Figure 1: MRUnot CD200/CD200R1 represents the rest of the MRUs.